So it may be necessary to repeat diazepam doses to maintain peak anticonvulsant effects, resulting in excess body accumulation.

What happens if I miss a dose?Take the missed dose as soon as you remember. A similar lorazepam dose given intravenously will result in an earlier and higher peak serum level, with a higher relative proportion of unmetabolised (active) lorazepam. nausea and vomiting caused or worsened by psychological sensitization to the thought of being sick. So it may be necessary to repeat diazepam doses to maintain peak anticonvulsant effects, resulting in excess body accumulation. Benzodiazepine treatment should be discontinued as soon as possible via a slow and gradual dose reduction regimen. * Liver or kidney failure – Lorazepam may be safer than most benzodiazepines in patients with impaired liver function. In medicinal form, lorazepam is mainly available as tablets and a solution for injection, but, in some locations, it is also available as a skin patch, an oral solution, and a sublingual tablet. See also: Ativan pregnancy and breastfeeding warnings (in more detail)The sedative effects of this medication may last longer in older adults. The prolonged sedation from lorazepam may, however, be an acceptable trade-off for its reliable duration of effects, particularly if the patient needs to be transferred to another facility. Cognitive impairment, behavioural disinhibition and respiratory depression as well as hypotension may also occur.