Lorazepam, as with other benzodiazepine drugs, can cause physical dependence, addiction, and what is known as the benzodiazepine withdrawal syndrome.

In addition to recreational use, benzodiazepines may be diverted and used to facilitate crime: Criminals may take them to deliberately seek disinhibition before committing crimes (which increases their potential for violence). government study of pharmaceutical-related ED visits by SAMHSA found that sedative-hypnotics in the United States are the pharmaceuticals most frequently used outside of their prescribed medical purpose, with 35% of drug-related emergency room visits involving sedative-hypnotics. Lorazepam is metabolised in the liver by conjugation into inactive lorazepam-glucuronide. It affects chemicals in the brain that may become unbalanced and cause anxiety. The higher doses and the longer periods benzodiazepines are taken increase the risk of developing a benzodiazepine dependence. Because of its high potency, the smallest lorazepam tablet strength of 0. Lorazepam was first introduced by Wyeth Pharmaceuticals in 1971 under the brand names of Ativan and Temesta. Lorazepam was first introduced by Wyeth Pharmaceuticals in 1971 under the brand names of Ativan and Temesta. High dose or prolonged parentally administered lorazepam is sometimes associated with propylene glycol intoxication. edit Special groups and situations* Children and the elderly – The safety and effectiveness of lorazepam is not well determined in children under 18 years of age, but it is used to treat acute seizures.