Benzodiazepine treatment should be discontinued as soon as possible via a slow and gradual dose reduction regimen.

Valproate, inhibits the metabolism of lorazepam, whereas carbamazepine, lamotrigine, phenobarbital, phenytoin, rifampin increases the rate of metabolism of lorazepam. Lorazepam is absorbed relatively slowly if given intramuscularly, a common route in restraint situations. Due to tolerance and dependence, lorazepam is recommended for short-term use, 2–4 weeks only. Otherwise, management is by observation, including of vital signs, support and, only if necessary, considering the hazards of doing so, giving intravenous flumazenil. They can add to sleepiness caused by this medication. After its introduction in 1977, lorazepam's principal use was in treating anxiety. It is also used as adjunct therapy for cyclic vomiting syndrome. Lorazepam should be avoided in patients with the following conditions:* Allergy or hypersensitivity – Past hypersensitivity or allergy to lorazepam, to any benzodiazepine, or to any of the ingredients in lorazepam tablets or injections * Severe respiratory failure – Benzodiazepines, including lorazepam, may depress central nervous system respiratory drive and are contraindicated in severe respiratory failure. * Surgical premedication – Informed consent that was given only after receiving lorazepam premedication could have its validity challenged later. If you have any of these conditions, you may need a dose adjustment or special tests to safely take Ativan.