Such allegations may arise because of incomplete amnesia, disinhibition, and impaired ability to process cues.

Toxicity from propylene glycol has been reported in the case of a patient receiving a continuous lorazepam infusion. Lorazepam injectable solution is administered either by deep intramuscular injection or by intravenous injection. Benzodiazepines, including lorazepam, have been found to increase the risk of falls and fractures in the elderly. This contrasts with the highly lipid-soluble diazepam, which, although rapidly absorbed orally or rectally, soon redistributes from the serum to other parts of the body, in particular body fat. Some antidepressants, anti-epileptic drugs such as phenobarbital, phenytoin and carbamazepine, sedative antihistamines, opiates, antipsychotics and alcohol when taken with lorazepam may result in enhanced sedative effects. Dose requirements have to be individualized, especially in the elderly and debilitated patients in whom the risk of oversedation is greater. 6. Reaction of the above product with acetic anhydride leads to a Polonovski type rearrangement reaction, giving a 3-acetoxylated benzodiazepine, 7-chloro-1,3-dihydro-3-acetoxy-5-(2′-chlorphenyl)-2H-benzodiazepin-2-one. 5. Longer-term use, up to six months, does not result in further accumulation.