It should, therefore, not be administered to a drunk or intoxicated person.

Withdrawal symptoms, including rebound insomnia and rebound anxiety, may occur after only 7 days' administration of lorazepam. For more information, contact the U. Of drugs used in attempted suicide, benzodiazepines are the most commonly used pharmaceutical drug, with 26% of attempted suicides involving benzodiazepines. The anxiolytic effects may also be detrimental to a patient's willingness and ability to fight for breath. gov/buyonlineguideBefore taking AtivanDo not use this medication if you have narrow-angle glaucoma, or if you are allergic to Ativan or to other benzodiazepines, such as alprazolam (Xanax), chlordiazepoxide (Librium), clorazepate (Tranxene), diazepam (Valium), or oxazepam (Serax). Lorazepam is metabolised in the liver by conjugation into inactive lorazepam-glucuronide. High dose or prolonged parentally administered lorazepam is sometimes associated with propylene glycol intoxication. In this category, benzodiazepines are most commonly used. But its poor lipid solubility and high degree of protein binding (85-90% ) mean that lorazepam's volume of distribution is mainly the vascular compartment, causing relatively prolonged peak effects. Signs of overdose range through mental confusion, dysarthria, paradoxical reactions, drowsiness, hypotonia, ataxia, hypotension, hypnotic state, coma, cardiovascular depression, respiratory depression, and death.