Due to its poor lipid solubility lorazepam is absorbed relatively slowly by mouth and is unsuitable for rectal administration.

It may further reduce the patient's ability to protect his or her airway during sleep. nausea and vomiting caused or worsened by psychological sensitization to the thought of being sick. It takes approximately 18–36 hours for the benzodiazepine to remove itself from the body. Such allegations may arise because of incomplete amnesia, disinhibition, and impaired ability to process cues. This list is not complete and there may be other drugs that can interact with Ativan. Lorazepam (initially marketed under the brand names Ativan and Temesta) is a high-potency short-to-intermediate-acting 3-hydroxy benzodiazepine drug that has all five intrinsic benzodiazepine effects: anxiolytic, amnesic, sedative/hypnotic, anticonvulsant and muscle relaxant. Recreational use, wherein the drug is taken to achieve a high, or when the drug is continued long term against medical advice. Peak effects roughly coincide with peak serum levels, which occur 10 minutes after intravenous injection, up to 60 minutes after intramuscular injection, and 90 to 120 minutes after oral administration, but initial effects will be noted before this. Otherwise, management is by observation, including of vital signs, support and, only if necessary, considering the hazards of doing so, giving intravenous flumazenil. 2-amino-2′,5-dichlorobenzophenone is reacted with hydroxylamine.